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Preclinical animal and in vitro studies are largely acute, yet chronic exposure better reflects real-world use 16 and may reveal mechanisms of fibrosis, tissue remodeling, and oxidative stress

Lazarus Nature Reviews Gastroenterology & Hepatology .2024

10.15698/cst2021.05.249 28 ChartierC.ElHawaryH.BaradaranA.VorstenboschJ.XuL.EfanovJ

Sepsis-induced lung injury further reveals the core role of the H3K18la-METTL3-ACSL4 axis, inducing mitochondrial fatty acid oxidation-dependent ferroptosis