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In addition to histones, deubiquitinating enzymes regulate autophagy by stabilizing nonhistone components of the autophagy machinery

Psychoneuroendocrinology (2012) 37:188595

Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease

It is important to note, that not only the increased production of ROS and RNS but also the decline in the efficiency of antioxidant systems with age leads to oxidative stress (Liguori et al., 2018)