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Quick answer In the REDEFINE trials CagriSema is given once weekly by subcutaneous injection, with both components titrated in parallel from 0.25 mg + 0.25 mg up to a 2.4 mg + 2.4 mg weekly target

Our physician injectors massage and form the filler as they place it, as needed (Volbella flows like water, so generally does not need this)

Then, the I-BAR domain of MIM was inserted into pHalo7- C1 or pmCherry-C1 plasmids at the same site as the pEGFP-C1-MIM I-BAR

A vial stored at 22C for 812 hours has experienced degradation equivalent to 57 days of proper refrigeration, and there's no way to measure remaining potency without high-performance liquid chromatography (HPLC) analysis