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In recent years, an increasing number of studies have focused on adjunctive therapeutic strategies aimed at further protecting dopaminergic neurons based on existing treatments, delaying disease progression, and improving patients quality of life

During sample collection an assessment as to whether an individual was affected with konzo was conducted following the WHOs 3 main criteria for diagnosis including evidence of (1) a visible symmetric spastic abnormality of gait while walking or running, (2) a history of onset of less than 1 week followed by a nonprogressive course in a formerly healthy person, and (3) bilaterally exaggerated knee or ankle jerks without signs of disease of the spine

Abstract Aims/hypothesis There is a growing need for markers that could help indicate the decline in beta cell function and recognise the need and efficacy of intervention in type 1 diabetes

In accordance, targeting of NRF2 is of high interest, due to its prominent roles in several neurodegenerative hallmarks