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Another short feedback loop involves the participation of BMAL1/CLOCK to activate the expression of REV-ERB and ROR through binding to the nuclear orphan receptor ( ROR ) at the promoter site (34, 62)

Several researchers have evaluated the potential of these phytocompounds (Table 3) and underlying anti ulcerative mechanisms using various animal models that have been summarized below: 6.4.1 Nitrogen containing compounds Nitrogen containing secondary metabolites, especially derived from medicinal plants exhibits a potent anti-inflammatory and immune regulating properties against UC [123]

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However, this cytoprotective effect did not translate into improved renal function, as dexamethasone exerted additional ferroptosis-independent effects on innate immune cell recruitment to injured kidneys