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In a randomized, double-blind comparison trial of 43 patients, pigment-correcting serum was compared with hydroquinone 4% and showed overall comparable efficacy to hydroquinone in patients with melasma and postinflammatory hyperpigmentation (Makino et al., 2016)

Research utilizing National Health and Nutrition Examination Survey (NHANES) data revealed that after adjusting for confounding factors including sex, age, body mass index, and smoking status, a significant positive association persisted between constipation and major depressive disorder (MDD) [odds ratio (OR) = 2.42, 95% confidence interval (CI): 1.863.14] (Wang et al., 2023)

For example, saponin is a natural surfactant found in leaves, roots, and seeds of many plants, such as quinoa, legumes, and tomatoes

It's called hyperpigmentation, and it can sometimes pop up as a temporary side effect of laser hair removal