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Enabling scientists to use human cells in their research, running additional experiments without rationing cells or limiting experimental scale Flow cytometry analysis demonstrates gene repression of CD81 upon lentiviral guide RNA delivery Repression levels depend on the chosen target and gRNA design No silencing of the transcriptional repression domain CRISPRi-Ready ioGlutamatergic Neurons form structural neuronal networks by day 11 CRISPRi-Ready ioGlutamatergic Neurons express neuron-specific markers CRISPRi-Ready ioGlutamatergic Neurons demonstrate gene expression of neuronal-specific and glutamatergic-specific markers following deterministic cell programming The dedicated User Manual for the CRISPRi-Ready ioGlutamatergic Neurons must be used for culture and gRNA delivery, and not the user manual for the wild-type ioGlutamatergic Neurons (io1001)

Virology 362 , 2637 (2007)

AOD-9604 has substantially more human data, with Phase 2 clinical trials involving over 300 participants dosed for 12 weeks

A phase ib/II study of sabizabulin, a novel oral cytoskeleton disruptor, in men with metastatic castration-resistant prostate cancer with progression on an androgen receptor-targeting agent