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55 Apart from the calcium-dependent eNOS activation, exercise also stimulates hormone and growth factor secretions such as norepinephrine (NE) and vascular endothelial growth factor (VEGF), which may bind to 3-AR and VEGFR in endothelial cells and further activate PI3K/AKT signaling and subsequent eNOS phosphorylation

-Scission of an alkoxyl radical derived from dihydroperoxide produces two -hydroxy-,-unsaturated aldehydes, i.e., a methyl-terminal HNE molecule and a mirror image of HNE, still esterified to PC (namely, 9-hydroxy-12-oxo-10-dodecenoic acid [HODA] or its PC ester from linoleate and 5-hydroxy-8-oxo-6-octenoic acid [HOOA] or its PC ester from arachidonate)