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Their principal advantages include dose-dependent estrogen suppression, fast reversibility of hormone secretion after treatment cessation, oral delivery, and avoidance of the flare-up effect

Symptoms may include: Skin rashes Itching Difficulty breathing Swelling of the face or throat If any severe allergic reaction occurs, immediate medical attention is necessary

Histidine itself has also been reported to have antioxidant properties, being a scavenger of free hydroxyl and singlet oxygen radicals and inhibiting fatty-acid oxidation during in vitro studies 51

The expression of CAV2 decreased as lymph node metastasis progressed, and the mRNA levels of CAV2 in N3 individuals were considerably reduced compared to N1 and N2 individuals (Fig