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iScience 24, 102245

However, sortilin binds to numerous ligands and plays a major role in mannose 6-phosphate receptor-independent transport of lysosomal hydrolases utilizing motifs in the intracellular domain that mediate trafficking from the Golgi and late endosomes

Bacterial contamination becomes a genuine concern, especially in multi-dose vials that have been punctured multiple times

Even if FDA eventually adds a substance to the 503A bulks list, that is not the same as approving a drug through clinical trials and labeling review (National Law Review)