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165 Among these, ensemble modelsparticularly random forest (RF) and XGBoosthave consistently demonstrated strong performance when applied to structured, tabular clinical datasets

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Despite promising preclinical results with inhibitors (e.g., ferrostatin-1) and gene therapies targeting GPX4/ACSL4, clinical translation faces critical barriers: the poorly defined temporal dynamics of ferroptosis post-stroke hinders therapeutic window optimization, and its interplay with necroptosis/pyroptosis requires clarification to guide combination therapies