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Database (Oxford) 2014, doi: 10.1093/database/bau051 (2014)

Altogether, these examples underscore that despite encouraging experimental results, ferroptosis-targeted drugs face multiple translational bottlenecks, including systemic toxicity, insufficient targeting, metabolic compensation, and biological heterogeneity

Izquierdo Lafuente, B., Ummels, R., Kuijl, C., Bitter, W

A novel combination therapy using Rosuvastatin and lactobacillus combats dextran sodium sulfate-induced colitis in high-fat diet-fed rats by targeting the TXNIP/NLRP3 interaction and influencing gut microbiome composition