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Sjgren T, Nord J, Ek M, Johansson P, Liu G, Geschwindner S (2013) Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

Despite the observed decreases in peripheral blood pressure and PWV, the AIx and central pulse pressure (PP) did not change significantly

J Mol Biochem

These limitations have motivated researchers to investigate alternative delivery methods that can bypass the BBB while ensuring sufficient patient compliance, preferably avoiding invasive routes like injections