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Hepatology 57 , 555565 (2013)

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DPP1 enables NSPs to acquire complete active conformation and biological function by precisely cleaving specific dipeptide sequences (typically Gly-Glu or Ser-Glu) from NSP precursor N-termini ( Recent investigations have identified a DPP1-like protease (NSPs-Alternative Activating Protease, NSPs-AAP), adding complexity to NSP activation mechanisms