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Moreover, studies have indicated that EGCG exerts a direct antioxidant effect by chelating free transition metals such as iron and copper (61)

Acknowledgments This work is part of the collaboration between the Department of Radiobiology and Molecular Genetics, VINA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia, Clinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia, and KAUST

Mutation of the kinase domain of LRRK2, G2019S, exacerbates ROS-induced dopaminergic neuronal death, and application of truncated LRRK2 reverses ROS accumulation and prevents morphological alteration of these neurons [52]