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Such disturbance may exacerbate autoimmune conditions like SLE, as defective SCFA generation might be responsible for intestinal wall disruption and modulation of immune signaling pathways, thereby leading to disease pathology ( 2.3 Sex-based differences in gut microbiota and their implications for SLE Mounting evidence indicates that the structure of gut microbiota differs drastically in women and men as a result of hormones, lifestyle, and diet ( SLE is a disease that primarily targets women, making it one of the known sex-specific autoimmune diseases