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Interestingly, ALS and frontotemporal dementia (FTD) are closely related conditions and often share both genetic and disease mechanisms, especially in people with C9ORF72 mutations suggesting they may be part of the same disease spectrum (Parobkova and Matej, 2021)

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Cell Mol Neurobiol 37:377388 MacDonald AJ, Robb JL, Morrissey NA, Beall C, Ellacott KL (2019) Astrocytes in neuroendocrine systems: An overview

For example, stimulation of a macrophage with cytokines such as IFNs or TNF has profound effects on the stoichiometry of NF-B pathway components and PRRs (80), which will affect their relative availability to the signaling cascade