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Description

Statins induce both mitochondrial oxidative stress and calcium-dependent permeability transition, which may lead to cell injury and death

However, the studies mentioned above commonly lack a comprehensive description of the complete pharmacokinetic profiles of the monomers investigated

Biomol 12(1), 20

While recurrence in hepatitis features was not observed, trial of pravastatin cannot be considered a true rechallenge, as structural differences between the statins may have accounted for the lack of recurrence