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Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

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Initial clinical trials with kisspeptin demonstrate potential to enhance implantation and pregnancy rates, while kisspeptin measurement can assist in evaluating reproductive health