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The systemic inflammatory response generated by the production of cytokines and chemokines during intestinal I/R injury might profoundly disrupt the bloodbrain barrier (BBB) (Guo et al., 2025)

Rights and permissions About this article Cite this article Gobburu, J.V.S., Agers, H., Jusko, W.J

In contrast, Bellomo et al

Probiotics and Gut Health The gut-brain axis is significantly influenced by the vagus nerve, which means that a healthy gut can positively affect vagal tone