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Description

Cytoplasmic signaling cascades mediated by PI3KAKT and the GTPases RAC1 or cell division control protein 42 (CDC42) modulate cell survival and elicit cytoskeletal changes

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The overexpression of EGFR reduces intracellular ROS levels through the PI3K/AKT pathway, thereby enhancing the metastatic potential of cancer cells [100] (Fig