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Fe and Cu mediate pyroptosis Several pathways contribute to pyroptosis, including the Caspase-1 activation-mediated classical pyroptotic pathway, Caspase-4/5/11-dependent nonclassical pyroptotic pathway, Caspase-8-dependent pyroptotic pathway and Caspase-3-dependent pyroptotic pathway [104]

In the fat-1 mouse model, which has the unique ability to endogenously transform n-6 PUFAs into n-3 PUFAs, the prevalence of Th17 cells in the spleen is notably diminished in contrast to wild-type IMQ-treated mice