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When the NNMT enzyme is overactive, its often associated with insulin resistance, a condition where your cells dont respond well to insulin and cant easily take up glucose from your blood

Taken together, these results suggest high selectivity of the small molecule 5-amino-1MQ analogue at pharmacologically relevant concentrations to NNMT-inhibition

By inhibiting this enzyme, 5-Amino-1MQ may increase the availability of nicotinamide for NAD+ biosynthesis while preserving SAM for other methylation reactions

The NNMT Inhibitor May Enhance Muscle Performance Through Increasing NAD+ The studys findings that the NNMT inhibitor, 5-amino-1MQ, improves muscle strength and endurance in aged mice may come from boosting NAD+ levels through increasing cellular levels of its precursor, nicotinamide