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Since ALS is a multisystemic disease, lymphoblasts have been increasingly used for this purpose since they share molecular mechanisms, such as protein aggregation, mitochondrial dysfunction, with degenerated motor neurons[52]

Once a decision is reached on whether to reopen the payment determination, additional time would be needed to complete recalculation of a payment determination (if warranted), and issue the revised initial determination to an ACO, or otherwise notify the ACO of our decision with respect to their reopening request