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Utilizing tools like the 36-Item Short Form Survey (SF-36), which includes domains specifically linked to neuropathy, underscores the profound impact of PN on overall health and well-being

Importantly, Fer-1 potentially exerts its anti-ferroptosis effect through accumulation within the ER, as opposed to lysosomes and mitochondria

These findings highlight the dual role of CHOP in both promoting inflammation through NF-B activation and potentially contributing to cellular apoptosis under prolonged ER stress conditions

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