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These spasms squeeze and irritate the nerves of the sacral plexus and create pain throughout the piriformis

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pernicious anemia refers to one of the hematologic manifestations of chronic auto-immune gastritis, in which the immune system targets the parietal cells of the stomach or intrinsic factor itself, leading to decreased absorption of vitamin B 12

Finally, hepatic impairment can affect gluconeogenesis and medication metabolism, though tirzepatide itself does not require dose adjustment in liver disease