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The Importance of Citric Acid: The major antagonist to calcium-based stones is citrate

Mol Cell Endocrinol 2012

Valproate-phenobarbital interaction: [1] Valproate may reduce phenobarbital metabolism

In summary, future research must integrate multi-omics, single-cell technologies, and cross-organ pathology to decode DS from molecular defects to circuit dysfunction, driving a paradigm shift from symptomatic control to mechanistic correction