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Inhibition of melanin dispersion Following melanin synthesis, one key step of melanogenesis in the skin is the translocation of mature melanosomes into keratinocytes, which are then transported up to the epidermidis where the melanin is dispersed

Western blot analysis Homogenized liver and spleen tissues, and splenocytes from spleen of WT mice and Jurkat T cells lysed by protein extraction solution (PRO-PREP, iNtRON Biotechnology) containing protease inhibitor cocktail (Calbiochem, Darmstadt, Germany) and phosphatase inhibitor cocktail (Roche, Basel, Switzerland)

instead, they start in another part of the atria or in the nearby pulmonary veins

It achieves this by curtailing the production of pro-inflammatory proteins and inhibiting pathways that escalate inflammation