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NAC strengthens antioxidant defenses and helps with detoxification to protect cellular components from damage

Perspect Sci 6, 6683

Abbreviations ABC: ATP-binding cassette ADCs: Antibody-drug conjugates ADCC: Antibody-dependent cellular cytotoxicity AML: Acute myeloid leukemia BBB: Blood-brain barrier CDx: Companion diagnostics CNS: Central nervous system DARs: Drug-to-antibody ratios DAMPs: Damage-associated molecular patterns DLBCL: Diffuse large B-cell lymphoma FDA: Food and Drug Administration FISH: Fluorescence in situ hybridization HPB: Hepatopancreatobiliary ICD: Immunogenic cell death IHC: Immunohistochemistry ILD: Interstitial lung disease LNPs: Lipid nanoparticles MDR: Multidrug resistance MMAF: Monomethyl auristatin F MMAE: Monomethyl auristatin E NSCLC: Non-small cell lung cancer OS: Overall survival ORR: Objective response rate PBD: Pyrrolobenzodiazepine PEG: Polyethylene glycol PFS: Progression-free survival PLD: Pegylated liposomal doxorubicin ROS: Reactive oxygen species RWE: Real-world evidence TAAs: Tumor-associated antigens TAMs: Tumor-associated macrophages TME: Tumor microenvironment TNBC: Triple-negative breast cancer TKI: Tyrosine kinase inhibitor References Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, et al

Comparing across all the Onygenales, we found that all pathogenic Onygenales, as well as saprophytes related to Coccidioides such as U