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Both nonclinical studies and some clinical investigations have demonstrated the cellular, neurochemical, neuroadaptive, and neuroplastic changes induced by escitalopram with acute and chronic administration

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This alters neuronal membrane potential and OS states, ultimately leading to neuronal death [23, 48, 49]

Safranal, a monoterpene aldehyde responsible for the characteristic smell of saffron, is an antioxidant that contributes to lowering oxidative stress in the neurons, inhibiting the production of pro-inflammatory cytokines and balancing the equilibrium between free radicals and antioxidants activity (Seyedinia et al., 2023)