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free radical scavenging activity, suppression of intracellular calcium influx, blockage of Na + channel activation, reduction of intracranial pressure, tissue edema, and inflammation ( DMSO is a powerful free radical scavenger and its utilization in a condition of oxidative stress may prevent the accumulation of free radicals that consumed the enzymatic antioxidants and reduce their levels ( + channel activation The Na + channel is activated by the physical impact on the brain tissue in TBI which leads to initiation of action potential and loss of membrane permeability culminating in necrosis and free radical generation (Torre et al., 1973) who first reported the potential therapeutic effect of DMSO in central nervous system injury