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Importantly, the animal study showed lower levels of ADAs in monkeys than in rats

Thus the majority of the pathway favors heme production

2.2 Recommended Dosage and Administration Non-Squamous NSCLC The recommended dosage of Pemetrexed Injection when administered with pembrolizumab and platinum chemotherapy for the initial treatment of metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes administered after pembrolizumab and prior to carboplatin or cisplatin on Day 1 of each 21-day cycle for 4 cycles

In vitro assessments demonstrated no signs of mutagenicity or cytotoxicity