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In human embryonic stem cells, CHAC2 is highly enriched and is crucial for maintaining self-renewal capacity

The effect of cumulative standardized statin dose and duration showed a significant interaction with age (interaction: p =0.0005 and p 10-fold variation of cirrhosis incidence between the bottom quintiles (1-2) and top quintile (5) of RF model risk (Table)

In the model cytosolic GSH has three fates: it is transported into the blood, there is a net flux to GSSG, and 0.2% is removed per hour corresponding to detoxification reactions and excretion into the bile

501 Activation of Nrf2 prevents ferroptosis by upregulating ferritin, SLC7A11 and GPX4