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Growth factor and chemokine signaling in tumor angiogenesis A large number of pro-angiogenic factors and their cognate receptors are known to promote vessel formation in tumors, including vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), platelet derived growth factor (PDGF), angiopoietins, ephrins, apelin (APLN) and chemokines

That safety profile is the primary reason providers across the country are using it in off-label clinical practice

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They consist of two main components: the nucleus pulposus (a gel-like center) and the annulus fibrosus (the tough outer layer)