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Acknowledgments The authors extend their appreciation to the Deputy ship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number ISP23-101

The most common adverse reactions that have been reported with topical azelaic acid formulations are burning, itching, stinging, dryness, and erythema which are temporary and mild (Kirsch et al., 2019

In addition, tryptophan depletion and kynurenine accumulation induce the formation of immunosuppressive regulatory T cells (Tregs), leading to tumor growth (Heng et al., 2016)

Glutathione Oral Supplementation: Glutathione oral supplements are convenient and simple to use, requiring no additional equipment or physician supervision