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Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent

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Synapse turnover, a highly dynamic and regulated process, was affected, with increased bouton numbers in nprl3 RNAi flies, suggesting that nprl3 inhibits bouton formation and/or promotes bouton elimination at the NMJ

The clearest signals are in eye disease using a drop formulation, such as neurotrophic keratopathy and dry eye [3] [4] , plus short-term infusion safety data in healthy volunteers [6]