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In the overall cohort, monocyte-to-lymphocyte ratio (MoLR) and neutrophil-to-lymphocyte ratio (NLR) had the best discriminative ability for 3-month outcome (AUC 0.65 and 0.64, respectively), with significant associations maintained in multivariable analysis adjusted for age, sex, onset-to-door delay, acute treatment, large-vessel occlusion, ASPECTS, NIHSS, active cancer, acute CRP, pre-stroke mRS (MoLR: aOR 1.01, 95%CI 1.001.01, p 2 group, all with available thrombi extracted during endovascular thrombectomy (EVT)

Research suggests MOTS-C may promote exercise capacity, metabolic flexibility, and healthy aging while helping maintain overall vitality and wellness

All other evidence is from rodent and in vitro models