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Phase I involves a transfer of a hydroxyl, a carboxyl, or an amino group to the toxic compound, which is often mediated by the cytochrome P450 enzymes

These disorders include neuromyelitis optica (NMO, also known as unilateral optic neuritis), isolated or recurrent transverse myelitis, longitudinally extensive transverse myelitis or isolated brain lesions with or without detectable anti AQP4-IgG autoantibody

Oxidative stress therefore leads to the accumulation of ROS, which, in turn, causes damage to our cells

Experimental design Five equal groups of eight cycled female rats each were randomly assigned to the following groups ( Fig