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Capitelli C, Sereniki A, Lima MM, Reksidler AB, Tufik S, Vital MA

In a DN model, human UCMSCs promote Nrf2 nuclear translocation through the PI3K/AKT signaling pathway, upregulate antioxidant factors such as HO-1 and SOD2, and consequently alleviate glomerulosclerosis and mesangial cell apoptosis [104]

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The senolytic effects varied between inducers and cell lines, but we identified 38 fragments (with diverse warheads, including chloroacetamides, cyanoacrylamides, acrylamides, aldehydes or sulfonyl fluorides) that selectively killed senescent cells in at least one of the three senescent conditions analysed (Fig