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Under the acidic microenvironment of the tumor, the hydrolysis of CAA induces self-assembly of Gi-F-CAA into large nanoparticles (Gi-F) due to the enhanced hydrophobic interaction

These antibody clones are classified into two distinct epitope bins, and all effectively block IL-33/ST2 reporter signaling in vitro , achieving IC50 values below 10 g/mL

Krasilnikova J, Lauberte L, Stoyanova E, Abadjieva D, Chervenkov M, Mori M, De Paolis E, Mladenova V, Telysheva G, Botta B, Kistanova E (2018) Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts

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