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doi: 10.1002/bies.201900046 [DOI] [PMC free article] [PubMed] [Google Scholar] 20

The neuro-ophthalmology of mitochondrial disease

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This non-essential amino acid can be transformed into glutamate and then into -ketoglutarate (KG), which like glucose-derived acetyl-CoA, is an essential fuel for the TCA cycle [ Fatty acids Fatty acids (FAs) can fuel cellular metabolism through FA oxidation (FAO), another source of acetyl-CoA, which can then be shuttled to the TCA cycle