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It causes an imbalance in the cellular oxidative homeostasis, which in turn triggers oxidative damage and ferroptosis

Pharmacokinetics: Mild symptoms : Patients exhibiting two or more mild symptoms of organophosphate poisoning (Table 1) : Administer one DuoDote injection intramuscularly into the lateral thigh muscle or buttocks (holding the injector for 10 seconds after it fires)

Recent studies have revealed the elevation of SIRT1 in a rat model of status epilepticus, a common neurological emergency which is defined as a prolonged seizure with at least five minutes or multiple seizures with incomplete recovery of consciousness [117] and its neuroprotection is conducted via deacetylation of proliferator-activated receptors and coactivator 1 (PGC-1), an important regulator for mitochondrial biogenesis [118, 119]

Pegadricase was well tolerated at all doses tested (Supplementary Table 3)