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Paradoxically, the resultant abnormal vasculature exacerbates hypoxic conditions and creates a vicious cycle, wherein the progressively abnormal TME continues to foster angiogenesis and hypoxia in tumors

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Also, those with SLE should be concerned about anemia, not only because of the symptoms that it causes (see below), but also because it may indicate a serious underlying issue, such as lupus nephritis or other kinds of kidney disease or failure

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