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RStudio and R-3.2.2 (53) ( was used for all statistical analysis, and significance was accepted at p 2 points or 1 SD in VABS-II composite scores were used to discriminate responders. Out of the 19 who completed the behavioral assessments in the CRWP group, 12 were identified as responders vs

(2020) 39:e104523

For each area, a subgroup of topic experts was assigned to prepare evidence-based background summaries, focusing on recent mechanistic studies, epidemiological data, and randomized clinical trials

Polyneuropathy typically presents gradually, beginning with paresthesia known as burning feet, followed by gait disturbances and variable muscle weakness in the lower limbs ( In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (42)