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However, one group reported that global GRK2 knockdown impaired kidney development, and increased blood pressure [43] while another group reported that Grk2 +/ mice have normal blood pressure and attenuated response to the hypertensive effect of Ang II infusion [31]
Where each stands and what the data shows The reported results put them in a rough order on efficacy, though cross-trial comparisons are not definitive
By coupling to many downstream intracellular cascades and effectors, the G proteins initiate pleiotropic changes in many intracellular targets
