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For example, miR-155 promotes Th17 cell responses through multiple mechanisms

It is likely that many of the other pathways that were affected by ibuprofen also show gender differences, but these pathways were not investigated in this study

The conclusion: given the low use concentrations involved, together with the negative repeated-dose toxicity, skin irritation and sensitisation, and genotoxicity findings, the Panel determined the available data support the safe use of these ingredients in cosmetic products