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doi: 10.1007/s12640-019-00157-0 67 DringenR.ScheiberI

We chose intranasal administration of UCT-MSC-EXs as we felt it delivered better efficacy than intravenous administration for crossing the BBB

Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]