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The PLGA-encapsulated formulation enhanced drug bioavailability while leveraging the Enhanced permeability and retention (EPR) effect for tumor-selective accumulation, addressing key pharmacokinetic limitations of free piperlongumine

Given that several membrane barriers need to be crossed, transcellular transport is generally expected to require more time compared to extracellular transport

For example, levels of glutathione, NADH, NAD + , and NADP were increased in the KO cells (Supplementary Fig

Editor information Editors and Affiliations Rights and permissions Copyright information 2014 Springer Science+Business Media New York About this chapter Cite this chapter Rook, D., van Goudoever, J.B