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Experimental evidence indicates that targeted BCAA or leucine supplementation can support mitochondrial function and aspects of muscle bioenergetics in aging models, although effects depend on dose, duration, and context (2426)

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Although previous studies identified that RIDD functions mainly in the clearance of ER-bound transcripts as a mechanism to reduce the load of ER client proteins during ER stress, more recent studies have also revealed an active role of RIDD in determining cell fate 61