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A meta-analysis [289] found essentially no benefit from melatonin

Astrocytes converts these FAs into KBs, which are then transported to neurons to serve as metabolism of energy (Panov et al

504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis